Investigate a variety of cell signaling pathways with Rockland’s comprehensive portfolio of products, including primary antibodies, cytokines, growth factors, and cell viability assays.
Cell signaling or signal transduction allows cells to communicate and send signals from the cell surface to the nucleus. This interaction of cells requires many different proteins, such as growth and transcription factors, to activate membrane receptors inside the cell before a physiological effect on the cell's behavior can be produced.
Any disruption or errors found within this communication chain gives rise to various diseases and cancers. So by understanding cell signaling, diseases may be treated more effectively and cures can be found.
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Phospho-specific Antibodies for Investigating Cell Signaling Pathways
Phosphorylation is essential for pathway activation in cellular regulation, cell signaling, and growth. Activated phospho proteins and reagents can trigger a cascade of reactions and interactions, which lead to cellular activation, motility, proliferation, and metabolic modifications. Due to the complex roles that phosphorylated proteins can play, accurately and precisely quantifying them at the cellular level is critical to deciphering and understanding cellular functions. Phospho-specific antibodies can discriminate between phosphorylated and non-phosphorylated forms and can be used to assess the degree of phosphorylation and to understand the function of any given protein.
Rockland also offers conjugated phospho-specific antibodies that can eliminate the need for a secondary antibody, allowing the use of a direct assay and avoiding potential cross-reactivity.
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