Rockland’s Epi-Plus™ line of highly specific, validated, antibodies recognize modified histones and related cellular targets. Epi-Plus™ antibodies are extremely sensitive and specific to the modification and show no cross-reactivity to other modifications on the same site or other amino acids of the protein. These antibodies are validated for immunofluorescence microscopy (IF), immunoprecipitation (IP), chromatin immunoprecipitation (ChIP), immunohistochemistry (IHC), and Western blot (WB) analysis.
Rockland carries panels of chromatin and nuclear signaling antibodies containing the highest quality reagents available for epigenetics research. These epigenetic antibodies are produced against Histone PTMs under rigorous quality control testing.
What are Epigenetic Tools?
Epigenetic tools consist of multicomponent cellular machinery referred to as readers, writers and erasers, and are responsible for altering gene expression patterns and determining the cellular phenotype without changing the genetic information encoded in the nucleotide sequence. Termed "Epigenetics" from the Greek word “epi,” this process can be described as a regulation “from above,” resulting in functionality-relevant modifications to the genetic material without alteration of the primary DNA sequence.
These modifications are inheritable, ensuring continued guidance of gene expression and resulting in the many cellular differentiation processes that make up an organism, which involve the acetylation and/or methylation of DNA or protein—referred to as “Epigenetic marks.”
Epigenetic marks are studied primarily in histones and other proteins that control the regulation of gene expression, transcription, and protein-protein interaction. They have been implicated in an array of human pathophysiological conditions that includes cancer, obesity, diabetes, drug addiction (addictive phenotypes in general), and post-traumatic stress disorder.
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