Thyroid Hormone Receptor beta 1 Antibody
Anti-THRB1 Antibody - Immunofluorescence
Anti-THRB1 Antibody - Western Blot
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Datasheet

Thyroid Hormone Receptor beta 1 Antibody

Rabbit Polyclonal

600-401-A96S 600-401-A96
25 µL 100 µg
ELISA, IF, WB, ChIP, IP
Human, Mouse
Rabbit
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$99.00 /Per Item
$399.00 /Per Item
25 µL $99.00
100 µg $399.00
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Description

Background

Anti-Thyroid Hormone Receptor ß1 (TRB1) antibody is designed, produced, and validated as part of a collaboration between Rockland and the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). This TRB1 antibody is ideal for Immunology, Thyroid and Signal Transduction research.

Application Note

This affinity purified antibody has been tested for use in ELISA, IF, and western blotting.

Purity/Specificity

This product was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody reacts with human THRB protein.  A BLAST analysis was used to suggest cross-reactivity with THRB from mouse, human and rat based on a 100% homology with the immunizing sequence.  Cross-reactivity with THRB from other sources has not been determined.

Anti-Thyroid Hormone Receptor ß1 (THRB1) (RABBIT) Antibody - 600-401-A96
Rabbit anti-THRB antibody, rabbit anti-Thyroid hormone receptor beta 1 antibody, Anti-THRB1 antibody, c-erbA-beta, THR1 antibody, c-erbA-2, Nuclear receptor subfamily 1 group A member 2, ERBA2, NR1A2
THRB
ELISA, IF, WB
ChIP, IP
Human
Human, Mouse
Rabbit
Polyclonal
IgG
Peptide
Anti-TR ß1 antibody is affinity purified from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the N-terminal of human THRB isoform 1 protein.
Liquid (sterile filtered)
1.15 mg/mL by UV absorbance at 280 nm
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
0.01% (w/v) Sodium Azide
None
Dry Ice
Store Anti-TR beta1 antibody at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of opening.
Park JW et al. Loss of tyrosine phosphorylation at Y406 abrogates the tumor suppressor functions of the thyroid hormone receptor β. Mol Carcinog. (2017)
Applications
WB, IB, PCA
Fozzatti L et al. Oncogenic actions of the nuclear receptor corepressor (NCOR1) in a mouse model of thyroid cancer. PloS One (2013)
Applications
IP, Co-IP
Zhao L et al. Role of TSH in the spontaneous development of asymmetrical thyroid carcinoma in mice with a targeted mutation in a single allele of the thyroid hormone-β receptor. Endocrinology. (2012)
Applications
IP, Co-IP
Mishra A et al. Adipogenesis is differentially impaired by thyroid hormone receptor mutant isoforms. J Mol Endocrinol. (2010)
Applications
ChIP

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If you need help finding your CofA, contact us

This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

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