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Datasheet

Thyroid Hormone Receptor alpha 1/2 Antibody

Mouse Monoclonal 2103 IgG1

209-301-E67
100 µL
Liquid
WB
Human, Rat
Mouse
$485.00 /Per Item
Availability: Ships in approximately 14 days
Shipping info:

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Background

Thyroid Hormone Receptor alpha 1/2 antibody detects TRα1 and TRα2. Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory. Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRα1, TRα2, TRβ1 and TRβ2. TRα1, TRβ1 and TRβ2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain. Anti-TRα1/ TRα2 Antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

Product Details

Anti-Thyroid Hormone Receptor alpha 1/2 (MOUSE) Monoclonal Antibody - 209-301-E67
mouse anti-Thyroid Hormone Receptor alpha 1/2 Antibody, mouse anti-Thra antibody, Nuclear receptor subfamily 1 group A member 1, V-erbA-related protein 7, EAR-7, c-erbA-1, c-erbA-alpha
Mouse
Monoclonal
IgG1

Target Details

THRA  - View All THRA Products
Human, Rat
Conjugated Peptide
Anti-Thyroid Hormone Receptor alpha 1/2 Monoclonal Antibody was produced by repeated immunizations with synthetic peptide corresponding to amino acid residues from the N-terminal region of Thyroid Hormone Receptor alpha.
Anti-Thyroid Hormone Receptor alpha 1/2 antibody is directed against human Thyroid Hormone Receptor alpha 1/2 protein and is specific for the TR-α1 and the TR-α2 proteins. Anti-Thyroid Hormone Receptor alpha 1/2 Antibody was purified by Protein G chromatography from cell culture supernatant followed by extensive dialysis against the buffer stated above. Expect reactivity with the following species based on 100% sequence homology: canine, mouse and rat.

Application Details

WB
Thyroid Hormone Receptor alpha 1/2 antibody has been tested for use in Western Blot. The expected bands in western blot are 50kDa for TR-α1 and 58 kDa for the TR-α2 proteins. Researchers should determine optimal titers for applications that are not stated below.

Formulation

0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
0.1 mg/ml Bovine Serum Albumin (BSA) - IgG and Protease free, 50% (v/v) Glycerol

Shipping & Handling

Dry Ice
Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.

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This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

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