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TACE Antibody

Rabbit Polyclonal

100 µg
Human, Rat
$475.00 /Per Item
Availability: Ships in approximately 14 days
Shipping info:

$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.


TACE Antibody detects TNF-alpha. Tumor-necrosis factor-alpha is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-alpha; is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-alpha;. TNF-alpha; converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFalpha, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association. Anti-TACE antibodies are ideal for investigators involved in Apoptosis and Cytokines and Growth factor research.

Product Details

Anti-TACE (RABBIT) Antibody - 600-401-H24

Target Details

ADAM17  - View All ADAM17 Products
Human, Rat
Conjugated Peptide
TACE Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide corresponding to amino acids near the c-terminus of human TACE. This sequence differs from those of mouse and rat TACE by one amino acid. The immunogen is located within the last 50 amino acids of TACE.
Anti-TACE Antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Predicted species reactivity based on immunogen sequence: mouse (94.1%). Cross-reactivity with TACE from other sources has not been determined.

Application Details

Anti-TACE Antibody is tested for use in ELISA, WB, ICC, and IF. Expect a band approximately ~93.0 kDa on specific lysates. 80 to 130kDa bands can be detected, which may represent mature protein, precursor and glycosylated TACE. Western Blot and Immunofluorescence tested in human and rat samples; Immunocytochemistry in human samples. Positive Control used HeLa Cells, Jurkat Cells, and Raji Cells. Specific conditions for reactivity should be optimized by the end user.


Liquid (sterile filtered)
1 mg/mL by UV absorbance at 280 nm
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
0.02% (w/v) Sodium Azide

Shipping & Handling

Dry Ice
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.

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This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.