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Datasheet

Coagulation Factor II Antibody

Rabbit Polyclonal

ABIN3187675
100 µL
Liquid
WB, ELISA, IHC
Human, Mouse, Rat
Rabbit
$439.00 /Per Item
Availability: Ships in approximately 14 days
Shipping info:

$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.

Product Details

Anti-Coagulation Factor II (thrombin) (F2) (Internal Region) Antibody - ABIN3187675
Prothrombin, Coagulation factor II, Prepro-Coagulation Factor II, Prothrombin B-Chain, Thrombin Factor II, EC 3.4.21, RPRGL2, THPH1, PT
Rabbit
Polyclonal
IgG

Target Details

F2  - View All F2 Products
Human, Mouse, Rat
Conjugated Peptide
Synthesized peptide derived from the Internal region of human Prothrombin.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Prothrombin Polyclonal Antibody detects endogenous levels of Prothrombin protein.
P00734 - UniProtKB
2147 - Gene ID

Application Details

ELISA, IHC, WB
Anti-Coagulation Factor II (thrombin) (F2) (Internal Region) Antibody is tested for use in ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC-P), and Western Blotting (WB). Expect a band approximately 70kDa in size corresponding to Prothrombin by western blotting in the appropriate cell lysate or extract.

Formulation

1.0 mg/mL by UV absorbance at 280 nm
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
0.02% (w/v) Sodium Azide
50% (v/v) Glycerol

Shipping & Handling

Wet Ice
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. Dilute only prior to immediate use. Stable for 12 months from date of receipt.
Expiration date is one (1) year from date of receipt.
This gene encodes the prothrombin protein (also known as coagulation factor II). This protein is proteolytically cleaved in multiple steps to form the activated serine protease thrombin. The activated thrombin enzyme plays an important role in thrombosis and hemostasis by converting fibrinogen to fibrin during blood clot formation, by stimulating platelet aggregation, and by activating additional coagulation factors. Thrombin also plays a role in cell proliferation, tissue repair, and angiogenesis as well as maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in this gene lead to various forms of thrombosis and dysprothrombinemia. Rapid increases in cytokine levels following coronavirus infections can dysregulate the coagulation cascade and produce thrombosis, compromised blood supply, and organ failure.

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This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.