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VAV1 protein-GST fusion

009-001-U55S 009-001-U55
20 µg 50 µg
Sf9 cells
$419.00 /Per Item
$805.00 /Per Item
Availability: Ships in approximately 30 days Availability: Ships in approximately 30 days
Shipping info:

$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.


VAV1 is a member of the VAV gene family which are guanine nucleotide exchange factors (GEFs) for Rho family GTPases. VAV1 activates pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. VAV1 is important in hematopoiesis, playing a role in T-cell and B-cell development and activation (1). VAV1 has been identified as the specific binding partner of Nef proteins from HIV-1. Co-expression and binding of Nef with VAV1 initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.VAV1 proto-oncogene participates in the signaling processes that mediate the antigen-induced activation of B lymphocytes (2). VAV1 Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Apoptosis/Autophagy, ERK/MAPK Pathway, JNK/SAPK Pathway, and p38 Pathway research.

Product Details

VAV1 recombinant protein-GST fusion protein - 009-001-U55
VAV, Proto-oncogene vav
Sf9 cells
Recombinant Protein

Target Details

Recombinant human VAV1 (amino acids 73-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal Glutathione-S-Transferase fusion protein. The purity was determined to be >70% by densitometry.

Application Details

VAV1 Protein is stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. VAV1 Protein is suitable for use in Western Blot. Expect a band approximately ~120kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.


Liquid (sterile filtered)
0.05 µg/µl
See application note.

Shipping & Handling

Dry Ice
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Expiration date is one (1) year from date of receipt.

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This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.