Tau phospho S416 Antibody
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Datasheet

Tau phospho S416 Antibody

Rabbit Polyclonal

612-401-E42
100 µL
Mouse, Rat
Rabbit
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$411.00 /Per Item
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Description

Background

Tau pS416 Antibody detects Tau, which s a key microtubule-associated protein that plays an important role in the formation of microtubules in axons. Six tau isoforms have been identified as products of a single gene produced by alternative mRNA splicing. Tau mutations have been implicated in many neurodegenerative disorders such as Alzheimer’s disease (AD), Pick’s disease and progressive supranuclear palsy. It has been well documented that hyperphosphorylated tau is a major component of paired helical filaments in AD brain. Serine 416 has been demonstrated to be a major phosphorylation site in vitro by CaM kinase II. Anti-Tau pS416 Antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

Application Note

Anti-Tau pS416 (Rabbit) antibody is suitable for use in Western Blotting. Expect bands approximately 59, 65, 68 kDa in size corresponding to tau proteins phosphorylated at Ser416 in the appropriate cell lysate or extract. Researchers should determine optimal titers for applications that are not stated below.

Purity/Specificity

Anti-Tau pS416 antibody is directed against rat Tau. Tau pS416 antibodies was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum. This antibody is directed against tau protein phosphorylated at Ser416. Reactivity is expected from the following species based on 100% sequence homology: bovine, canine, human, mouse and non-human primates.

Storage Condition

Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Anti-Tau pS416 (Rabbit) Antibody - 612-401-E42
Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau
Mapt
Rat
Mouse, Rat
Phosphorylation
Rabbit
Polyclonal
IgG
Peptide
Anti-Tau pS416 Antibody was produced in rabbit by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser416 of the Tau protein.
Liquid
Dry Ice
Expiration date is one (1) year from date of opening.
Titrated value sufficient to run approximately 10 mini blots.
0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
0.1 mg/ml Bovine Serum Albumin (BSA) - IgG and Protease free, 50% (v/v) Glycerol

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This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.