Synapsin I phospho S603 Antibody
Western blot of Synapsin I Ser603 Antibody
Western Blot of Anti-Synapsin I pS603
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Datasheet

Synapsin I phospho S603 Antibody

Rabbit Polyclonal

612-401-C95
100 µL
WB
Mouse, Rat
Rabbit
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Description

Background

Synapsin I pS603 antibody is directed against rat Synapsin I, whcih plays a key role in synaptic plasticity in brain. This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation. Serine 603 is the site on synapsin I that is phosphorylated by calcium calmodulin kinase II and by p21-activated kinases. Phosphorylation of this site is thought to regulate synaptic vesicle function. Anti-Synapsin I pS603 Antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

Application Note

Anti-Synapsin I pS603 (Rabbit) antibody is tested for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 78 kDa in size corresponding to synapsin I doublet protein phosphorylated at Ser603.

Purity/Specificity

Anti-Synapsin I pS603 antibody is directed against bovine Synapsin I. The antibody detects Synapsin I that is phosphorylated at S603. The Anti-Synapsin I pS603 antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Immunolabeling of the synapsin I band is blocked by lambda-phosphatase treatment. Reactivity is expected from the following species based on 100% sequence homology: human, Xenopus, bovine, zebra fish.

Anti-Synapsin I pS603 (Rabbit) Antibody - 612-401-C95
Synapsin I, SYN1, Synapsin-1
Syn1
WB
Rat
Mouse, Rat
Phosphorylation
Rabbit
Polyclonal
IgG
Peptide
Anti-Synapsin I pS603 Antibody was produced in rabbit by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser603 of Synapsin I.
Liquid
0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
0.1 mg/ml Bovine Serum Albumin (BSA) - IgG and Protease free, 50% (v/v) Glycerol
Dry Ice
Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
Expiration date is one (1) year from date of opening.
Engholm-Keller K et al. The temporal profile of activity-dependent presynaptic phospho-signalling reveals long-lasting patterns of poststimulus regulation. PLoS Biol. (2019)
Applications
WB, IB, PCA
Hammond et al. Platelet Activating Factor Enhances Synaptic Vesicle Exocytosis Via PKC, Elevated Intracellular Calcium, and Modulation of Synapsin 1 Dynamics and Phosphorylation. Frontiers in Cellular Neuroscience (2016)
Applications
WB, IB, PCA

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This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

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