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Datasheet

SHANK2 Antibody

Mouse Monoclonal N23b/6 IgG1

200-301-G44
100 µg
Liquid (sterile filtered)
WB, IHC, IF, IP
Human, Mouse, Rat
Mouse
This product is discontinued

Background

Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina. Other recent studies suggest that the disruption of glutamate receptors at the shank post synaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimer’s disease.

Product Details

Anti-SHANK2 (MOUSE) Monoclonal Antibody - 200-301-G44
SH3 and multiple ankyrin repeat domains protein 2, Shank2, Cortactin-binding protein 1, CortBP1, GKAP/SAPAP-interacting protein, Proline-rich synapse-associated protein 1, ProSAP1, SPANK-3
Mouse
Monoclonal
IgG1

Target Details

Shank2  - View All Shank2 Products
Human, Mouse, Rat
Recombinant Protein
SHANK2 Antibody was produced in mice by repeated immunizations raised against a fusion protein corresponding to an internal region of (SH3/PDZ domains) of rat Shank2 (SH3 and multiple ankyrin repeat domains protein 2.
Anti-SHANK2 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with SHANK2 from human, mouse, and rat based on 100% homology with the immunizing sequence. No cross-reactivity against Shank1 or Shank3. Cross-reactivity with Shank2 from other sources has not been determined. Scaffolds research.
Q9QX74 - UniProtKB
NP_958738.1 - NCBI Protein

Application Details

IF, IHC, IP, WB
Anti-SHANK2 Antibody is tested for use in WB, IHC, IF, and IP. Expect a band approximately ~160kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Formulation

1mg/mL by UV absorbance at 280 nm
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
0.09% (w/v) Sodium Azide
50% (v/v) Glycerol

Shipping & Handling

Dry Ice
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.

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This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

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