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Datasheet SDS

p70 S6 Kinase Antibody

Rabbit Polyclonal

600-401-942
100 µg
Liquid (sterile filtered)
WB, ELISA, IP
Mouse
Rabbit
$475.00 /Per Item
Availability: Ships in approximately 14 days
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$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.

Background

The protein p70 S6 kinase is critical for cell cycle progression and cell survival. In response to mitogen stimulation, p70 S6 kinase activation up-regulates ribosomal biosynthesis and enhances the translational capacity. p70S6K phosphorylates the S6 protein of the 40S subunit of the ribosome. This kinase was first characterized as an insulin/mitogen-activated protein kinase, whose major known substrate is the 40S ribosomal subunit protein S6. p70S6K is activated by diverse stimuli through multi-site phosphorylation at positions such as Thr-252 and Ser-434. In Alzheimer's Disease, p70S6K activation is associated with PHF-tau (hyperphosphorylated tau) accumulation. In non-neuronal cells, p70S6K has been shown to regulate actin polymerization.

Product Details

Anti-p70 S6 Kinase (RABBIT) Antibody - 600-401-942
p70S6Kb antibody, Ribosomal protein S6 kinase 70kDa, polypeptide 2 antibody, Ribosomal protein S6 kinase beta 2 antibody
Rabbit
Polyclonal
IgG

Target Details

RPS6KB1  - View All RPS6KB1 Products
Mouse
Conjugated Peptide
This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the carboxy terminal end of human p70S6K protein.
This affinity-purified antibody is directed against the human p70S6K protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification.  A BLAST analysis was used to suggest cross reactivity with p70S6K proteins from human, rat and mouse.  Reactivity against homologues from other sources is not known.
P23443 - UniProtKB
54041234 - NCBI Protein
6198 - Gene ID

Application Details

ELISA, IP, WB
This affinity purified antibody has been tested for use in ELISA, immunoprecipitation and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a predominant band approximately 70 kDa in size corresponding to p70S6K by western blotting in the appropriate cell lysate or extract.

Formulation

1.0 mg/mL by UV absorbance at 280 nm
0.1 M Tris Chloride, 0.5 M Sodium Chloride, pH 8.0
0.01% (w/v) Sodium Azide
None

Shipping & Handling

Dry Ice
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.

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This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.