NGFR Antibody
Immunocytochemistry of NGFR Antibody
Western Blot of NGFR Antibody
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Datasheet

NGFR Antibody

Rabbit Polyclonal

600-401-DA5
100 µg
ELISA, IF, IHC, WB
Human, Mouse
Rabbit
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$411.00 /Per Item
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Description

Background

The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-kB and various mitogen-activated protein kinases. Nerve growth factor receptor (NGFR) was one of the earliest characterized members of this family. Also known as the low-affinity receptor p75NTR, this receptor is involved in several diverse functions such as apoptosis, neurite outgrowth during development, and myelination. Its ligands include NGF, brain-derived neurotrophic factor (BDNF), NT3, and NT4. NGFR can also associate with other NGF receptors such as Trk through the cytosolic and transmembrane domains and thus can function as a co-receptor that refines Trk affinity and specificity for neurotrophins. Finally, upon binding of various neurotrophins, NGFR associates with tumor necrosis factor receptor-6 (TRAF6), suggesting that it can potentially function as a signal transducer for NGF signals through NGFR.

Application Note

Anti-NGFR Antibody has been tested for use in ELISA, Western Blotting, Immunocytochemistry, and immunofluorescence. Expect a band at approximately 45 kDa in Western Blots of specific cell lysates and tissues. Western Blot and Immunofluorescence tested in human samples, Immunocytochemistry in mouse samples. Specific conditions for reactivity should be optimized by the end user.

Purity/Specificity

Anti-NGFR Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with NGFR from other sources has not been determined.

Anti-NGFR (RABBIT) Antibody - 600-401-DA5
NGFR Antibody, CD271, p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, Tumor necrosis factor receptor superfamily member 16, NGF receptor
NGFR
ELISA, IF, IHC, WB
Human, Mouse
Rabbit
Polyclonal
IgG
Recombinant Protein
Anti-NGFR antibody was prepared from whole rabbit serum produced by repeated immunizations with purified recombinant human NGFR.
Liquid (sterile filtered)
1 mg/mL by UV absorbance at 280 nm
0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
0.02% (w/v) Sodium Azide
None
Dry Ice
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of opening.

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This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

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