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Nav1.8 Antibody
Mouse Monoclonal S134 IgG2a
200-301-G22
100 µg
Liquid (sterile filtered)
WB, IHC, IF
Human, Mouse, Rat, Monkey
Mouse
Shipping info:
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Product Details
Anti-Nav1.8 (MOUSE) Monoclonal Antibody - 200-301-G22
PN3, Na(V)1.8, Scn10a, Sodium channel protein type 10 subunit alpha, Peripheral nerve sodium channel 3, Sensory neuron sodium channel, Sodium channel protein type X subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.8
Mouse
Monoclonal
IgG2a
Target Details
Scn10a - View All Scn10a Products
Human, Mouse, Rat, Monkey
Recombinant Protein
Nav1.8 Antibody was produced in mice by repeated immunizations raised against a fusion protein corresponding near the cytoplasmic C-terminus region of rat Nav1.8.
Anti-NAV1.8 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with NAV1.8 from human, mouse, and rat based on 100% homology with the immunizing sequence. No cross reactivity against other Nav channels. Cross-reactivity with NAV1.8 from other sources has not been determined. Ion Channels research.
Q62968 - UniProtKB
NP_058943.1 - NCBI Protein
Application Details
IF, IHC, WB
Anti-NAV1.8 Antibody is tested for use in WB, IHC-P, and IF microscopy. Expect a band approximately ~220kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.
Formulation
1.0 mg/mL by UV absorbance at 280 nm
1X PBS, pH 7.4
0.09% (w/v) Sodium Azide
50% (v/v) Glycerol
Shipping & Handling
Wet Ice
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
Nav1.8 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.8 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.8 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals.
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.