Ki-67 Antibody
Rabbit Monoclonal SP6 IgG
Background
The MKI67 gene encodes a nuclear protein termed Ki-67 that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. Two isoforms have been reported, with isoform 1 transcribed as the longer transcript. Ki-67 is a nuclear protein predominantly localized in the G1 phase in the perinucleolar region. In later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes.
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