![Histone H4 [p Ser1] Immunofluorescence](https://rocklandwebimagescdn.azureedge.net/webimages/600-401-I96-HistoneH4-pS1-Antibody-1-IF-4x3.jpg "Histone H4 [p Ser1] Immunofluorescence")
![Histone H4 [p Ser1] Western Blot](https://rocklandwebimagescdn.azureedge.net/webimages/600-401-I96-HistoneH4-pS1-Antibody-2-WB-2x5.jpg "Histone H4 [p Ser1] Western Blot")
![Histone H4 [p Ser1] Immunofluorescence](https://rocklandwebimagescdn.azureedge.net/webimages/600-401-I96-HistoneH4-pS1-Antibody-3-IF-4x3.jpg "Histone H4 [p Ser1] Immunofluorescence")
![Histone H4 [p Ser1] ChIP](https://rocklandwebimagescdn.azureedge.net/webimages/600-401-I96-HistoneH4-pS1-Antibody-4-ChIP-4x3.jpg "Histone H4 [p Ser1] ChIP")
![Histone H4 [p Ser1] Dot Blot](https://rocklandwebimagescdn.azureedge.net/webimages/600-401-I96-HistoneH4-pS1-Antibody-5-DB-4x3.jpg "Histone H4 [p Ser1] Dot Blot")
Histone H4 phospho S1 Antibody
Rabbit Polyclonal
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Background
Chromatin is the arrangement of DNA and proteins in which chromosomes are formed. Correspondingly, chromatin is formed from nucleosomes, which are comprised of a set of four histone proteins (H2A, H2B, H3, H4) wrapped with DNA. Chromatin is a very dynamic structure in which numerous post-translational modifications work together to activate or repress the availability of DNA to be copied, transcribed, or repaired. These marks decide which DNA will be open and commonly active (euchromatin) or tightly wound to prevent access and activation (heterochromatin). Common histone modifications include methylation of lysine and arginine, acetylation of lysine, phosphorylation of threonine and serine, and sumoylation, biotinylation, and ubiquitylation of lysine. In particular, phosphorylation of H4 Ser1 (H4 pS1) has been linked to mitosis and DNA repair. This modification is enriched in sites proximal to double stranded brakes, but not those associated with UV damage. Casein kinase II (CK2) phosphorylates H4 Ser1, and it also implicated in regulating the DNA damage response. Furthermore, recruitment of CK2 requires the SIN3/RPD3 histone deacetylase complex. Anti-Histone H4 are ideal for researchers interested in DNA Repair, Chromatin Modifiers, Chromatin Research, Histones and Modified Histones, DNA replication Transcription Translation and Splicing, and Epigenetics research.
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This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.