![Histone H3 [Sym-dimethyl Arg2, Dimethyl Lys4] Immunofluorescence](https://rocklandwebimagescdn.azureedge.net/webimages/600-401-I85-HistoneH3-R2me2sK4me2-Antibody-1-IF-4x3.jpg "Histone H3 [Sym-dimethyl Arg2, Dimethyl Lys4] Immunofluorescence")
![Histone H3 [Sym-dimethyl Arg2, Dimethyl Lys4] Western Blot](https://rocklandwebimagescdn.azureedge.net/webimages/600-401-I85-HistoneH3-R2me2sK4me2-Antibody-2-WB-2x5.jpg "Histone H3 [Sym-dimethyl Arg2, Dimethyl Lys4] Western Blot")
![Histone H3 [Sym-dimethyl Arg2, Dimethyl Lys4] ChIP](https://rocklandwebimagescdn.azureedge.net/webimages/600-401-I85-HistoneH3-R2me2sK4me2-Antibody-3-ChIP-4x3.jpg "Histone H3 [Sym-dimethyl Arg2, Dimethyl Lys4] ChIP")
![Histone H3 [Sym-dimethyl Arg2, Dimethyl Lys4] Western Blot](https://rocklandwebimagescdn.azureedge.net/webimages/600-401-I85-HistoneH3-R2me2sK4me2-Antibody-4-WB-2x5.jpg "Histone H3 [Sym-dimethyl Arg2, Dimethyl Lys4] Western Blot")
![Histone H3 [Sym-dimethyl Arg2, Dimethyl Lys4] Dot Blot](https://rocklandwebimagescdn.azureedge.net/webimages/600-401-I85-HistoneH3-R2me2sK4me2-Antibody-5-DB-4x3.jpg "Histone H3 [Sym-dimethyl Arg2, Dimethyl Lys4] Dot Blot")
Histone H3 R2me2s/K4me2 Antibody
Rabbit Polyclonal
$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.
Background
Chromatin is the arrangement of DNA and proteins in which chromosomes are formed. Correspondingly, chromatin is formed from nucleosomes, which are comprised of a set of four histone proteins (H2A, H2B, H3, H4) wrapped with DNA. Chromatin is a very dynamic structure in which numerous post-translational modifications work together to activate or repress the availability of DNA to be copied, transcribed, or repaired. These marks decide which DNA will be open and commonly active (euchromatin) or tightly wound to prevent access and activation (heterochromatin). Common histone modifications include methylation of lysine and arginine, acetylation of lysine, phosphorylation of threonine and serine, and sumoylation, biotinylation, and ubiquitylation of lysine. The dimethylation of both arginine 2 (H3 Arg2Me2) and lysine 4 (H3 K4Me2) of H3 are both known marks to have opposing affects. Arg2Me2 maintains transcriptional silence by silencing Set1 mediated K4 methylation, in which K4 methylation is normally associated with active chromatin. The protein arginine methyltransferase PRMT6 can methylate H3R2 in vivo, and overexpression of this enzyme downregulates Hox and Myc dependent genes, both of which are targets of H3 K4 methylation. Anti-Histone H3 are ideal for researchers interested in Chromatin Modifiers, Chromatin Research, Histones and Modified Histones, and Epigenetics research.
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This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.