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Datasheet

DR5 Antibody

Rabbit Polyclonal IgG

200-401-H72
100 µg
Liquid
WB, IHC, IF, FC
Human
Rabbit
$525.00 /Per Item
Availability: Ships in approximately 14 days
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Background

DR5 TRAILR2 antibody detects human DR5 TrailR2. Apoptosis induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB. Anti DR5 TRAILR2 is ideal for investigators involved in apoptosis and NF-kappa B research.

Product Details

Anti-DR5 (RABBIT) Antibody - 200-401-H72
Tumor necrosis factor receptor superfamily member 10B, TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9, Death receptor 5, TNF-related apoptosis-inducing ligand receptor 2, TRAIL receptor 2, TRAIL-R2, CD_antigen=CD262
Rabbit
Polyclonal
IgG

Target Details

TNFRSF10B  - View All TNFRSF10B Products
Human
Conjugated Peptide
DR5 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide corresponding to amino acids near the c-terminus of human DR5.
Anti-DR5 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with DR5 TRAILR2 from Human based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-DR5 TRAILR2 from other sources has not been determined.
O14763 - UniProtKB
NP_003833.4 - NCBI Protein

Application Details

FC, IF, IHC, WB
Anti-DR5 Antibody is tested for use in WB, Flow, Flow-CS, ICC/IF, IHC, IHC-P. Expect a band approximately 47.9 kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Formulation

1.0 mg/mL by UV absorbance at 280 nm
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
0.05% (w/v) Sodium Azide
0.05% BSA

Shipping & Handling

Dry Ice
Store DR5 antibody at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.

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This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

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