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Coagulation Factor XI Antibody

Mouse Monoclonal 2B7E12F8 IgG1

100 µL
$293.00 /Per Item
Availability: Ships in approximately 14 days
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$50.00 to US & $70.00 to Canada for most products. Final costs are calculated at checkout.


Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the presence of calcium ions. It is an unusual dimeric protease with structural features that distinguish it from vitamin K-dependent coagulation proteases. The factor XI is synthesized in the liver as a single polypeptide chain with a molecular weight estimated between 125 ~160 kDa and then is processed into a disulfide-bond linked homodimer. FXI is a homodimer with each subunit containing four apple domains and a protease domain. The apple domains form a disk structure with binding sites for platelets high molecular weight kininogen and the substrate factor IX (FIX). FXI is converted to the active protease FXIa by cleavage of the Arg369-Ile370 bond on each subunit. After the activation reaction Factor XIa is composed of two heavy and two light chains held together by three disulfide bonds. The heavy chains are derived from the amino termini of the zymogen and responsible for the binding of factor XI to high molecular weight kininogen and for the activation of factor IX while the light chain contains the catalytic portion of the enzyme and is homologous to the trypsin family of serine proteases. FXI deficiency is a disorder characterized by a mild or no bleeding tendency. Severe FXI deficiency is an injury-related bleeding disorder common in Ashkenazi Jews and rare worldwide.

Product Details

Anti-Coagulation Factor XI (F11) (AA 1-625) (MOUSE) Antibody - ABIN1996321
Coagulation Factor XI, FXI, Plasma Thromboplastin Antecedent, PTA, Coagualtion Factor XI, EC, EC 3.4.21

Target Details

Recombinant Protein
Recombinant Human FXI protein (AA 1-625).
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified recombinant Human Factor XI. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. Specific to Human FXI, F11, Factor XI. No cross-reactivity in WB and ELISA with Human uPA/PLAU, Human Kallikrein-11/KLK-11, Human Kallikrein-1/KLK-1, Human HGFA/HGF Activator, Human cell lysate (293 cell line).

Application Details

Anti-Coagulation Factor XI (F11) (AA 1-625) Antibody is tested for use in ELISA. This antibody can be used at 0.5-1µg/mL with the appropriate secondary reagents to detect Human Factor XI. The detection limit for Human Factor XI is 0.039 ng/well.


Liquid (sterile filtered)
1.0 µg/µL by UV absorbance at 280 nm
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
<5% Trehalose

Shipping & Handling

Wet Ice
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Stable for 12 months from date of receipt. Avoid cycles of freezing and thawing. This product is preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). Dilute only prior to immediate use. This antibody can be stored at 2-8°C for one month without detectable loss of activity.
Expiration date is one (1) year from date of receipt.

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This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.