Gene Therapy Analytical Services
Gene Therapy Analytical Services
Advancing gene therapies requires precise, reproducible analytics at every stage of development. Rockland provides flexible services to support viral vector research, from upstream production and purification to detailed analytical characterization. Our solutions assist in generating high-quality research-grade material and reliable insights into vector quality and performance.
Supporting the Gene Therapy Development Journey
Every gene therapy program moves through a series of critical steps, from vector design and plasmid construction to GMP-scale manufacturing. Rockland focuses where precision matters most—upstream production, purification, and analytical characterization—enabling you to produce consistent viral vector material, prepare for preclinical studies, and make confident decisions about vector quality.
Upstream Production
Produce High-Yield Virus Pools with Reliable Upstream Workflows
Reproducible vector production begins with optimized upstream methods. Rockland supports gene therapy development with research-grade viral vector production services tailored to your payload, serotype, and expression system. Our scalable capabilities include:
- Cell culture expansion in adherent or suspension formats
- Transient transfection
- Virus harvest and clarification
- Small- to mid-scale viral vector pool generation
Purify and Concentrate Vectors for Research or Preclinical Use
Clean, functional vectors are essential for early-stage research and analytical testing. Rockland offers downstream processing methods to deliver research-grade samples suitable for assay development, QC testing, and preclinical evaluation. Our downstream capabilities include:
- Cesium chloride gradient ultracentrifugation for high-purity vector stocks
- Tangential flow filtration (TFF) for vector concentration and buffer exchange
- Clarification of harvested virus-containing supernatants fraction
Analytical Characterization
Characterize with High-Precision Analytics
Robust analytics drive confident development decisions. Rockland provides a comprehensive suite of assays to quantify, characterize, and validate viral vectors, including:
- Digital droplet PCR (ddPCR) for genome copy number
- Capsid quantification via ELISA
- Neutralization assays for evaluating preexisting immunity
- Infectivity assays in relevant cells
- DNA purification and sterility testing
With absolute quantification and reproducible workflows, Rockland’s analytical services provide the clarity needed to compare yields, validate batches, and advance IND-enabling studies.
Interested in Gene Therapy Analytical Services?
Meet with us to find out how we can help.